IMBRUVICA® Resource Library

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When you want to explore new information or try a new skill, get started with one of these downloadable resources. From tips for talking with your doctor to ways to set goals during treatment, these resources have got you covered.

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Featured Resource: Building a Medication Routine

When you take IMBRUVICA® as prescribed, you’re giving it the best chance to work.1 Create a routine that helps you take IMBRUVICA® according to your doctor’s directions.

I’m Getting Started With IMBRUVICA®

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    IMBRUVICA® Cost and Coverage Brochure
    Find answers to some questions you may have about insurance coverage, out-of-pocket costs, and potential financial support options for IMBRUVICA®.

    Download the Brochure

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    YOU&i™ Patient Education Brochure
    Learn about IMBRUVICA®, understand possible side effects, build your medication routine, and keep track of how you feel during treatment.

    Download the Brochure

I Need Help Communicating With My Care Team

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    Making the Most of Your Doctor's Appointments
    Good doctor's appointments happen when you and your doctor understand each other and work together on treatment goals. Try these tips to help set yourself up for a productive appointment.

    Download the Doctor Conversation Guide

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    Talking to Your Doctor About Side Effects
    IMBRUVICA® can cause side effects.1 Learn about some of the serious and common side effects, and make sure you tell your doctor about what you experience.

    Download the Side Effect Info Sheet

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    Reaching Out for Support
    A support network of friends and family can help you throughout your treatment. Build a support network that works for you.

    Download the Support Network Tool

I Need Help Building My Routine With IMBRUVICA®

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    Staying on Track With Your Treatment Plan
    Setting and reaching goals can help you stay motivated throughout your treatment. Work with your healthcare team to set some goals and track your progress.

    Download the Goal Setting Tool

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    Treatment Tracking Calendars
    Keep track of your symptoms, side effects, and medical appointments with customizable treatment calendars you can print at home.

    Download the Tracking Calendar

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    Taking Your DOSE
    Update this tool with your best ideas for how to make taking IMBRUVICA® as your doctor prescribed part of your daily routine.

    Download the DOSE Tool

I Need Help Caring for Someone Taking IMBRUVICA®

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    Supporting a Friend or Family Member
    When you’re caring for someone with cancer, it’s important to take care of yourself, too! Check out these tips for supporting both of you.

    Download the Caregiver Planning Tool


1. IMBRUVICA® (ibrutinib) Prescribing Information. Pharmacyclics LLC. 2020.

Grow Your Circle of Support

Joining a support group can help you meet others who may be going through some of the same experiences as you and talk about the struggles and successes of treatment.

Try these sites or ask your doctor to suggest a support group near you.

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American Cancer Society
Click to visit website

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Cancer Support Community
Click to visit website

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Leukemia & Lymphoma Society
Click to visit website

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International Waldenstrom's Macroglobulinemia Foundation
Click to visit website

YOU&i Support Program Logo (white)

No matter where you are with your IMBRUVICA® treatment, the YOU&i™ Support Program is here to help.

Sign Up for Support

If you haven’t been prescribed IMBRUVICA® yet, visit to learn more about IMBRUVICA® as a potential treatment option.


Before taking IMBRUVICA®, tell your healthcare provider about all of your medical conditions, including if you:

  • have had recent surgery or plan to have surgery. Your healthcare provider may stop IMBRUVICA® for any planned medical, surgical, or dental procedure.
  • have bleeding problems.
  • have or had heart rhythm problems, smoke, or have a medical condition that increases your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes.
  • have an infection.
  • have liver problems.
  • are pregnant or plan to become pregnant. IMBRUVICA® can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with IMBRUVICA®. Tell your healthcare provider if you are pregnant or think you may be pregnant during treatment with IMBRUVICA®.
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment with IMBRUVICA® and for 1 month after the last dose.
    • Males with female partners who are able to become pregnant should use effective birth control, such as condoms, during treatment with IMBRUVICA® and for 1 month after the last dose.
  • are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with IMBRUVICA® and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.

How should I take IMBRUVICA®?

  • Take IMBRUVICA® exactly as your healthcare provider tells you to take it.
  • Take IMBRUVICA® 1 time a day.
  • Swallow IMBRUVICA® capsules or tablets whole with a glass of water.
  • Do not open, break or chew IMBRUVICA® capsules.
  • Do not cut, crush or chew IMBRUVICA® tablets.
  • Take IMBRUVICA® at about the same time each day.
  • If you miss a dose of IMBRUVICA® take it as soon as you remember on the same day. Take your next dose of IMBRUVICA® at your regular time on the next day. Do not take extra doses of IMBRUVICA® to make up for a missed dose.
  • If you take too much IMBRUVICA® call your healthcare provider or go to the nearest hospital emergency room right away.

What should I avoid while taking IMBRUVICA®?

  • You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood.

What are the possible side effects of IMBRUVICA®?

IMBRUVICA® may cause serious side effects, including:

  • Bleeding problems (hemorrhage) are common during treatment with IMBRUVICA®, and can also be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs of bleeding, including: blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding, or bleeding that is severe or that you cannot control, vomit blood or vomit looks like coffee grounds, cough up blood or blood clots, increased bruising, dizziness, weakness, confusion, change in your speech, or a headache that lasts a long time or severe headache.
  • Infections can happen during treatment with IMBRUVICA®. These infections can be serious and may lead to death. Tell your healthcare provider right away if you have fever, chills, weakness, confusion, or other signs or symptoms of an infection during treatment with IMBRUVICA®.
  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA®, but can also be severe. Your healthcare provider should do monthly blood tests to check your blood counts.
  • Heart rhythm problems (ventricular arrhythmias, atrial fibrillation and atrial flutter). Serious heart rhythm problems and death have happened in people treated with IMBRUVICA®, especially in people who have an increased risk for heart disease, have an infection, or who have had heart rhythm problems in the past. Tell your healthcare provider if you get any symptoms of heart rhythm problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, chest discomfort, or you faint. If you develop any of these symptoms, your healthcare provider may do a test to check your heart (ECG) and may change your IMBRUVICA® dose.
  • High blood pressure (hypertension). New or worsening high blood pressure has happened in people treated with IMBRUVICA®. Your healthcare provider may start you on blood pressure medicine or change current medicines to treat your blood pressure.
  • Second primary cancers. New cancers have happened during treatment with IMBRUVICA®, including cancers of the skin or other organs.
  • Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your healthcare provider may do blood tests to check you for TLS.

The most common side effects of IMBRUVICA® in adults with B-cell malignancies (MCL, CLL/SLL, WM and MZL) include:

  • diarrhea
  • tiredness
  • muscle and bone pain
  • rash
  • bruising

The most common side effects of IMBRUVICA® in adults with cGVHD include:

  • tiredness
  • bruising
  • diarrhea
  • mouth sores (stomatitis)
  • muscle spasms
  • nausea
  • pneumonia

Diarrhea is a common side effect in people who take IMBRUVICA®. Drink plenty of fluids during treatment with IMBRUVICA® to help reduce your risk of losing too much fluid (dehydration) due to diarrhea. Tell your healthcare provider if you have diarrhea that does not go away.

These are not all the possible side effects of IMBRUVICA®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of IMBRUVICA®

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use IMBRUVICA® for a condition for which it was not prescribed. Do not give IMBRUVICA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about IMBRUVICA® that is written for health professionals.

Please see the full Important Product Information.


What is IMBRUVICA® (ibrutinib)?

IMBRUVICA® (ibrutinib) is a prescription medicine used to treat adults with:

  • Mantle cell lymphoma (MCL) who have received at least one prior treatment
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion
  • Waldenström’s macroglobulinemia (WM)
  • Marginal zone lymphoma (MZL) who require a medicine by mouth or injection (systemic therapy) and have received a certain type of prior treatment
  • Chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy

It is not known if IMBRUVICA® is safe and effective in children.



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IMBRUVICA® (ibrutinib) is covered by U.S. Patents, which are listed in FDA's Orange Book (available at

© Pharmacyclics LLC 2020 © Janssen Biotech, Inc. 2020 07/20 PRC-06886